beta -Arrestin 1(Phospho-Ser412) Rabbit Polyclonal Antibody
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Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones| neurotransmitters| or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system| it is expressed at high levels in peripheral blood leukocytes| and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
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This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
ARRB1 encodes arrestin beta 1, the human beta-arrestin-1 protein. Beta-arrestin-1 is a cytosolic regulator of agonist-activated G protein-coupled receptors (GPCRs), coordinating receptor desensitization, internalization and subsequent trafficking. Abmium catalogue products linked below support research into ARRB1 expression and GPCR regulatory biology.
Biological function: Beta-arrestin-1 binds activated, phosphorylated GPCRs and limits further coupling to cognate G proteins, contributing to homologous receptor desensitization. It also functions as an endocytic adaptor, recruiting components including AP-2 and clathrin-associated machinery to promote receptor internalization. These activities place ARRB1 at an important control point between receptor activation, trafficking and resensitization.
