BMP-10 Polyclonal Antibody
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The bone morphogenetic protein 10 encoded by BMP10 is a member of the TGF-beta family of growth factors. Data suggest that the similar protein in mouse plays an important role in trabeculation of the embryonic heart. In human, this protein may signal through receptor serine/threonine kinases.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Evidence | WB | ELISA |
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| Applications |
This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
Bone morphogenetic protein 10 (BMP10; BMP-10) is a secreted TGF-beta superfamily ligand with prominent cardiovascular biology. It signals through type I BMP/activin receptors, particularly ACVRL1/ALK1, to regulate SMAD-dependent programmes involved in cardiac and vascular development.
Biological function: BMP10 is synthesized as a preproprotein and proteolytically processed to a mature secreted ligand. Reviewed UniProt supports signalling through ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6 with activation of SMAD1, SMAD5 and SMAD8. Curated evidence links BMP10 to maintenance of embryonic cardiomyocyte proliferation and regulation of heart morphogenesis, while endothelial responses include control of migration and growth.
