ApoA-V Polyclonal Antibody
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The apolipoprotein A5 by APOA5 is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
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This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
APOA5 (apolipoprotein A5) encodes apolipoprotein A-V (ApoA-V), a liver-enriched minor apolipoprotein associated mainly with HDL and also with triglyceride-rich lipoproteins. APOA5 is an important regulator of plasma triglyceride metabolism and is studied in lipoprotein lipase activity, VLDL handling and systemic lipid homeostasis.
Biological function: Apolipoprotein A-V is a minor plasma apolipoprotein that modulates triglyceride-rich lipoprotein metabolism. Reviewed UniProt describes ApoA-V as a potent stimulator of apo-CII-dependent lipoprotein lipase triglyceride hydrolysis and as an inhibitor of hepatic VLDL-triglyceride production, supporting efficient triglyceride clearance and regulation of circulating triglyceride levels.
