ADM Polyclonal Antibody
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Adrenomedullin encoded by ADM is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E.coli and S. aureus at low concentration.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
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This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
Adrenomedullin (ADM; AM) is produced from the pro-adrenomedullin precursor, which also gives rise to proadrenomedullin N-terminal peptide (PAMP). Human ADM is represented by NCBI Gene 133 and reviewed UniProtKB P35318, with related ABMIUM catalogue reagents for research use.
Biological function: The ADM gene encodes pro-adrenomedullin, a precursor processed into biologically active peptides including adrenomedullin and PAMP. Curated NCBI and UniProt records describe adrenomedullin as a vasoactive peptide with potent vasodilatory and hypotensive activity and roles in fluid and electrolyte homeostasis; reviewed UniProt identifies signalling through CALCRL-RAMP2 and CALCRL-RAMP3 receptor complexes.
