Amyloid-beta Polyclonal Antibody
Know who made it. See the evidence. Buy through one marketplace.
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation| while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition| two of the peptides are antimicrobial peptides| having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Evidence | WB | IHC-p | IF |
|---|---|---|---|
| Applications |
This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
Amyloid beta precursor protein (APP; amyloid-beta precursor protein) is a type I transmembrane protein that is processed by secretases into multiple biologically active fragments, including soluble APP forms and amyloid-beta peptides. It is studied in neuronal growth, adhesion, synaptic biology and amyloid processing.
Biological function: Reviewed UniProt describes APP as a cell-surface receptor with physiological roles in neurite growth, neuronal adhesion, axonogenesis and synaptogenesis. Proteolytic processing generates soluble APP fragments and amyloid-beta peptides, while intracellular interactions contribute to signalling and transcriptional regulation.
