ABMIUM target intelligence
TNF receptor superfamily member 11b
TNFRSF11B identifies TNF receptor superfamily member 11b in Homo sapiens (Human). This target record connects NCBI Gene 4982, UniProtKB O00300 and related ABMIUM catalogue products.
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Research context & evidence
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TNFRSF11B (osteoprotegerin, OPG) is a secreted decoy receptor in the TNF receptor superfamily that binds TNFSF11/RANKL and limits RANKL-driven osteoclast differentiation and activation, thereby acting as a negative regulator of bone resorption.
TNFRSF11B/OPG is widely studied in bone remodeling, osteoclast biology, the RANKL-OPG axis and vascular calcification. ABMIUM research products associated with TNFRSF11B can support studies of expression and extracellular signaling; confirm species, application, sample type and product-level validation before use.
Names used across publications, databases and supplier catalogues.
