BMAL1 polyclonal antibody; host Rabbit; reactivity Human, Mouse, Rat
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aryl hydrocarbon receptor nuclear translocator like(ARNTL) Homo sapiens The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014],
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | WB | IHC-P | IF | ELISA |
|---|---|---|---|---|
| Human,Mouse,Rat |
This product is manufactured by Reed Biotech and sold through ABMIUM without relabelling.
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Basic helix-loop-helix ARNT like 1 (BMAL1; ARNTL) is a core bHLH-PAS circadian transcription factor. BMAL1 heterodimerizes with CLOCK or NPAS2 to drive E-box-dependent transcription that helps generate daily rhythms in gene expression, metabolism and physiology.
Biological function: BMAL1 forms transcriptionally active heterodimers with CLOCK or NPAS2 and binds E-box regulatory elements in circadian target genes. Its activity drives molecular-clock transcriptional programs and supports feedback loops that generate approximately 24-hour rhythms in gene expression.
