Custom research services · ABMIUM
Custom mRNA-LNP Development
Custom mRNA synthesis and lipid nanoparticle formulation for research. Discuss sequence design, capping, purity, encapsulation, particle QC and functional testing.
Specification reviewed before feasibility, pricing and lead time are confirmed.
Built around the experiment
Your project. A defined technical scope.
ABMIUM coordinates custom messenger RNA and lipid nanoparticle (mRNA-LNP) projects for research gene delivery. The service can connect sequence design, in vitro transcription, capping and purification to encapsulation and experimental assessment. Start with the protein or construct to express, the intended cell or model and the required amount. Delivery and expression performance need evaluation in the relevant system; they should not be inferred from the payload sequence alone.
Specialist ProMab service routes can be coordinated through ABMIUM. Your quotation identifies the selected provider, agreed stages, available documentation and material or experimental deliverables.
ABMIUM reviews your specification and coordinates suitable custom-service and manufacturing routes. The proposed provider or manufacturer, available documentation and agreed scope are stated before order.
Choose the stages you need
Service modules
Start with one module or combine related stages into a clearly scoped project.
mRNA design and IVT synthesis
Provide the coding sequence or protein target and discuss transcript design requirements. Include relevant untranslated regions, modifications and any sequence constraints. In...
Technical scope
Provide the coding sequence or protein target and discuss transcript design requirements. Include relevant untranslated regions, modifications and any sequence constraints. In vitro transcription and the final amount or concentration are defined in the starting scope.
Capping, purification and RNA QC
Discuss capping and purification with an analytical package matched to the project. Specify identity, integrity, concentration and other QC questions that affect...
Technical scope
Discuss capping and purification with an analytical package matched to the project. Specify identity, integrity, concentration and other QC questions that affect your use. The agreed documentation distinguishes material characterisation from biological expression testing.
LNP formulation and encapsulation
Request encapsulation of a defined mRNA payload and state the intended model, dose range and formulation constraints. Include storage and handling requirements....
Technical scope
Request encapsulation of a defined mRNA payload and state the intended model, dose range and formulation constraints. Include storage and handling requirements. The technical review confirms available formulation options, characterisation and the amount of material to supply.
In vitro validation, animal studies and scale-up
Scope expression, cell compatibility and relevant functional readouts before a larger supply stage. Animal studies can be assessed as a separate module....
Technical scope
Scope expression, cell compatibility and relevant functional readouts before a larger supply stage. Animal studies can be assessed as a separate module. Research scale-up, QC and ionisable-lipid licensing enquiries should specify the required stage, technical needs and commercial context.
Connect the service to your research
Research applications
Vaccine and antigen-expression research
Explore expression of a defined antigen in an experimental system, with appropriate expression and response readouts.
Immune-cell engineering
Discuss mRNA payloads for CARs, transgenes or other immune-cell research constructs and define the intended cell population.
Protein and antibody expression research
Investigate expression of proteins, antibody-related constructs or regenerative-biology factors as research applications.
Cancer immunotherapy research
Explore expression of a defined research payload in an immuno-oncology model. Include the target, cells, controls and immune-response endpoints so formulation and experimental assessment can be scoped together.
Protein-replacement research
Discuss expression of a protein payload in a specified research system. State the protein, model, expression-duration question and functional readout. Research expression data does not itself establish a therapeutic replacement product.
Cell and gene therapy research
Evaluate mRNA delivery as an input to a defined cell- or gene-engineering experiment. Specify recipient populations, payload, expression requirements and the measurements needed to compare delivery approaches.
Antibody and bispecific expression research
Discuss mRNA encoding an antibody-related construct, with expression and binding or functional assays agreed in the project plan. Provide sequences, format and the intended experimental system.
Regenerative-biology research
Explore delivery of research factors in a defined cell or model system. Include the payload, phenotype or functional endpoints and required controls so the expression study addresses a clear biological question.
Agree the output before work begins
Project deliverables
Material, experiments and documentation are defined in the quotation. Select the deliverables that your study needs.
- Custom mRNA, encapsulated material or a staged development package.
- Transcript and formulation information within the agreed scope.
- Analytical QC and expression or functional data for commissioned tests.
- Handling, scale-up and licensing terms where specifically agreed.
One coordinated route
How your custom project works
- 01
Share your requirement
Tell us the target, application, starting materials and output you need. Include performance and documentation requirements.
- 02
Review feasibility and scope
ABMIUM coordinates the technical review and identifies the proposed provider, methods, deliverables and project stages.
- 03
Confirm the quotation
Review the agreed specification, available QC and reports, pricing, indicative lead time and delivery terms before order.
Clear answers before you enquire
Frequently asked questions
Can I order custom mRNA without LNP encapsulation?
Specify the desired output at enquiry. Synthesis, purification, encapsulation and testing can be discussed as separate or connected stages.
Can mRNA-LNP be assessed in my cell type?
Provide the cell type and available assay system. Feasibility and validation should be reviewed for that context rather than extrapolated from another model.
What information is needed for an encapsulation quote?
Include the payload sequence or identity, amount, intended model, formulation requirements and required QC or expression studies.
Can I ask about research scale-up or lipid licensing?
Yes. State the scale, project stage and licensing question. Availability, terms and documentation are confirmed separately; no blanket clinical or GMP claim is made.
Should we request naked mRNA or an mRNA-LNP formulation?
That depends on the delivery experiment. Cell-culture work using a separate transfection reagent may need a different deliverable from a formulated delivery study. Specify the cell model, route, dose basis and planned readout before deciding whether RNA production and formulation belong in the same project.
Which mRNA and LNP quality attributes should we specify?
For RNA, discuss identity, integrity, concentration, capping and relevant impurities. For the formulation, discuss particle size distribution, encapsulation, RNA content, stability and a suitable functional readout. Analytical attributes and acceptance criteria should be stated in the scope.
What affects the cost of custom mrna-lnp development?
Pricing depends on RNA design and scale, purification, formulation screening, particle analytics, stability and functional testing. ABMIUM provides a project-specific quotation after reviewing the requirement. Ask for a breakdown of stages, deliverables, optional studies and further-work decision points so you can compare the total scope rather than an entry price alone.
Talk to ABMIUM
Request a technical review & quote
Share the information below to help us scope custom mrna-lnp development.
- Coding sequence or target protein and transcript-design requirements.
- Intended cells or model and the research application.
- mRNA amount, formulation, concentration and delivery requirements.
- QC, expression readouts, controls and scale-up or licensing needs.
info@abmium.com
+44 (0)203 824 9119
UK-based ABMIUM supports research enquiries from the UK, Europe and the United States. Include your destination country so material transfer, delivery and documentation requirements can be assessed. Research Use Only; feasibility and lead time are confirmed against the final specification.