ABMIUM target intelligence
basic helix-loop-helix ARNT like 1
Basic helix-loop-helix ARNT like 1 (BMAL1; ARNTL) is a core bHLH-PAS circadian transcription factor. BMAL1 heterodimerizes with CLOCK or NPAS2 to drive E-box-dependent transcription that helps generate daily rhythms in gene expression, metabolism and physiology.
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Research context & evidence
Target information is kept separate from product-level validation so you can review the biology and the reagent evidence independently.
BMAL1 forms transcriptionally active heterodimers with CLOCK or NPAS2 and binds E-box regulatory elements in circadian target genes. Its activity drives molecular-clock transcriptional programs and supports feedback loops that generate approximately 24-hour rhythms in gene expression.
BMAL1/ARNTL reagents support circadian-clock research, including transcriptional rhythmicity, clock-gene regulation, metabolism and time-of-day-dependent cell biology. Interpretation should consider sampling time, synchronization conditions and tissue-specific clock state.
Names used across publications, databases and supplier catalogues.
