ABMIUM target intelligence
BCL2 like 1
BCL2 like 1 (BCL2L1) encodes Bcl-2-like protein 1, whose major splice isoforms include anti-apoptotic Bcl-xL and pro-apoptotic Bcl-xS. This BCL-2-family regulator is central to mitochondrial apoptosis and cell-survival research.
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Names used across publications, databases and supplier catalogues.
BCL2L1 produces Bcl-2-like protein 1 isoforms with opposing effects on apoptosis. Bcl-xL inhibits cell death by limiting mitochondrial cytochrome-c release and caspase activation, whereas Bcl-xS promotes apoptosis. The reviewed human protein is also implicated in cell-cycle checkpoint regulation.
BCL2L1 / Bcl-xL is widely studied in intrinsic apoptosis, mitochondrial cell-death signalling, BCL-2-family biology and cancer models. Interpret reagent results in light of isoform specificity, epitope or clone, species, sample type, assay format and product-level validation.