ABMIUM target intelligence
programmed cell death 1
PDCD1 identifies programmed cell death 1 in Homo sapiens (Human). This target record connects NCBI Gene 5133, UniProtKB Q15116 and related ABMIUM catalogue products.
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Names used across publications, databases and supplier catalogues.
PDCD1 encodes programmed cell death protein 1 (PD-1/CD279), an inhibitory immune receptor expressed on antigen-activated lymphocytes. Engagement by PD-L1/CD274 or PD-L2/PDCD1LG2 attenuates activation signalling and contributes to peripheral immune tolerance, making the pathway a major regulator of T-cell responses.
PDCD1/PD-1 is a central target in immune-checkpoint, T-cell exhaustion, chronic infection, autoimmunity and cancer immunology research. Expression and functional impact depend on cell type, activation state, ligand availability and tissue context, so measurements should be interpreted with complementary immune-state markers and product-level validation.