ABMIUM target intelligence
carbonic anhydrase 2
Carbonic anhydrase 2 (CA2; carbonic anhydrase II/CA-II, also CAC) is a highly active cytosolic zinc metalloenzyme that reversibly hydrates carbon dioxide. Researchers study CA2 in bicarbonate handling, intracellular pH control, renal physiology, bone biology and carbonic-anhydrase enzymology.
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Research context & evidence
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CA2 catalyses the reversible interconversion of carbon dioxide and water with bicarbonate and protons. Its high catalytic efficiency supports rapid CO2/bicarbonate equilibration and acid-base homeostasis, and CA2 can participate in membrane-associated bicarbonate-transport complexes despite being primarily cytosolic.
CA2 is widely studied in carbonic-anhydrase catalysis, pH regulation, bicarbonate transport, renal acid-base handling and skeletal physiology. Because several carbonic anhydrase isozymes share related chemistry, isoform-specific detection and inhibitor selectivity are important experimental considerations.
Names used across publications, databases and supplier catalogues.
