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ElabscienceABMIUM Verified™
Anti-Human BCL6 Antikörper [A139]
SKU: ABM2153-1Primärantikörper
- Target
- BCL6
- Reactivity
- Mensch
- Applications
- WB, IHC
- Host
- Kaninchen
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BCL6 transcription repressor
BCL6 encodes a sequence-specific transcriptional repressor central to germinal-centre biology and antibody affinity maturation. This target record connects reviewed human BCL6 identifiers and aliases with ABMIUM catalogue products targeting BCL6.
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Research context & evidence
Target information is kept separate from product-level validation so you can review the biology and the reagent evidence independently.
BCL6 is a transcriptional repressor required for germinal-centre formation and antibody affinity maturation. It forms complexes with corepressors and histone deacetylases to repress distinct target-gene programmes, helping germinal-centre B cells proliferate while tolerating physiological DNA breaks associated with class-switch recombination and somatic hypermutation. BCL6 also contributes to follicular helper T-cell differentiation and immunological memory.
BCL6 is widely studied in germinal-centre B-cell biology, lymphoid differentiation, transcriptional repression, DNA-damage responses and lymphoma. Reagent choice should account for species, cellular localisation, assay format, clone or epitope, and product-level validation, particularly when comparing normal germinal-centre expression with malignant B-cell models.
Names used across publications, databases and supplier catalogues.