ABMIUM target intelligence
carbonic anhydrase 4
Carbonic anhydrase 4 (CA4; carbonic anhydrase IV/CA-IV) is a GPI-anchored membrane zinc metalloenzyme with an extracellular catalytic domain. It catalyses reversible CO2 hydration and is studied in extracellular pH regulation, bicarbonate transport, renal physiology and retinal acid handling.
Read full target overviewABMIUM research catalogue
Loading products for CA4…
Names used across publications, databases and supplier catalogues.
CA4 catalyses reversible conversion of carbon dioxide and water to bicarbonate and protons at the cell surface, helping couple extracellular carbon chemistry to pH homeostasis. Reviewed UniProt also supports roles in bicarbonate-transporter activity and retinal acid removal.
CA4 research spans membrane-associated carbonic-anhydrase catalysis, renal bicarbonate handling, capillary CO2 exchange, retinal pH homeostasis and transporter coupling. Its extracellular, GPI-anchored localisation differentiates it experimentally from cytosolic CA1 to CA3.