ABMIUM target intelligence
baculoviral IAP repeat containing 5
BIRC5 (baculoviral IAP repeat containing 5), widely known as survivin, is an inhibitor-of-apoptosis-family protein studied for its roles in mitotic progression, chromosome segregation and cell-survival regulation.
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Research context & evidence
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BIRC5 encodes survivin, a single-BIR-domain member of the inhibitor of apoptosis protein family. Beyond regulation of apoptotic cell death, survivin is a component of mitotic chromosome-passenger machinery and contributes to accurate chromosome segregation and cytokinesis. Multiple transcript variants encode distinct isoforms.
BIRC5/survivin is studied in mitosis, chromosome-passenger-complex biology, cytokinesis, proliferative cell states and apoptosis regulation. Research commonly measures BIRC5 expression, localization and isoform-specific behaviour when examining cell-cycle and survival pathways.
Names used across publications, databases and supplier catalogues.
