ABMIUM target intelligence
amyloid P component, serum
APCS (amyloid P component, serum; serum amyloid P-component or SAP) is a secreted pentraxin-family glycoprotein. It is a calcium-dependent ligand-binding protein found in serum and is characteristically associated with amyloid deposits.
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Research context & evidence
Target information is kept separate from product-level validation so you can review the biology and the reagent evidence independently.
Serum amyloid P-component forms a pentamer and binds calcium. Reviewed UniProt evidence supports interactions with DNA and histones, a potential role in scavenging nuclear material released from damaged cells, and calcium-dependent lectin activity; NCBI also describes binding to amyloid cross-beta structures and apoptotic cells.
APCS/SAP is studied in pentraxin biology, extracellular protein aggregation, amyloid-associated processes, chromatin clearance and innate homeostatic responses. Confirm species, sample type, assay format, application and product-level validation when selecting an ABMIUM APCS-associated reagent.
Names used across publications, databases and supplier catalogues.
