ABMIUM target intelligence

ADAMTS4

ADAM metallopeptidase with thrombospondin type 1 motif 4

ADAM metallopeptidase with thrombospondin type 1 motif 4 (ADAMTS4/ADAMTS-4), also known as aggrecanase-1, is an extracellular matrix metalloprotease strongly associated with proteoglycan turnover.

Read full target overview
OrganismMultiple species; representative: Homo sapiens (Human) NCBI Gene9507 UniProtO75173

ADAMTS4 products

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Human ADAMTS4 ELISA Kit PicoKine® Boster Bio
Boster BioABMIUM Verified™

Human ADAMTS4 ELISA Kit PicoKine®

SKU: ABM32957ELISA Kits
Target
A disintegrin and metalloproteinase with thrombospondin m...
Reactivity
Human
Sensitivity
<20 pg/ml
Detection range
625 pg/ml - 40,000 pg/ml
Sample types
Cell culture supernatantCell lysatesserum and plasma (hep...
£375.70£442.00 Save 15%
Available to order
Anti-ADAMTS4/ADAMTS4 Antibody Picoband® Boster Bio
Boster BioABMIUM Verified™

Anti-ADAMTS4/ADAMTS4 Antibody Picoband®

SKU: ABM27351-1Primary Antibodies
Target
A disintegrin and metalloproteinase with thrombospondin m...
Host
Rabbit
Clonality
Polyclonal
Reactivity
Rat, Mouse, Human
Applications
ELISA, Flow Cytometry, IHC, IHC-P, WB
From£278.80£328.00 Save 15%
Available to order
Comparing

Research context & evidence

About ADAMTS4

Target information is kept separate from product-level validation so you can review the biology and the reagent evidence independently.

Biology

Biological function

ADAMTS4, also known as aggrecanase-1, is a secreted ADAMTS-family metalloprotease. Curated NCBI and reviewed UniProt annotations describe cleavage of aggrecan and cartilage oligomeric matrix protein (COMP); NCBI also reports brevican degradation.

Experimental context

Research context

ADAMTS4 is studied in extracellular-matrix remodelling, aggrecan turnover, cartilage degradation and arthritis-related biology. Reagent selection should be based on species, sample type, assay format, application and product-level validation.

Identifiers

Alternative names

Names used across publications, databases and supplier catalogues.

A disintegrin and metalloproteinase with thrombospondin motifs 4ADAMTS-2ADMP-1ATS4KIAA0688UNQ769/PRO1563ADAMTS-4Aggrecanase-1