ABMIUM target intelligence
bone marrow stromal cell antigen 2
BST2 (bone marrow stromal cell antigen 2), also known as tetherin, CD317 and HM1.24, is an interferon-inducible membrane protein studied as a cell-intrinsic antiviral restriction factor and marker of innate immune activation.
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Research context & evidence
Target information is kept separate from product-level validation so you can review the biology and the reagent evidence independently.
BST2/tetherin restricts the release of diverse enveloped viruses by physically tethering nascent virions to infected-cell membranes. Its unusual membrane anchoring enables retained virions to remain at the surface or undergo endocytic internalization, linking BST2 to antiviral restriction, membrane trafficking and interferon-responsive host defence.
BST2 is used in research on interferon-stimulated antiviral defence, host-virus interactions, membrane trafficking and innate immune signalling. Abmium catalogue products linked below provide target-specific starting points; species, sample type, assay format, application and product-level validation should be checked for each reagent.
Names used across publications, databases and supplier catalogues.
