A potent and reversible inhibitor of IP3-mediated Ca2+ release, IC50 = 358 nM. Experiments with guinea-pig ileum permeabilized with alpha toxin revealed that Xestospongin C inhibits the IP3 receptor but not the ryanodine receptor in SR membranes. It is a useful tool for probing the involvement...
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A potent and reversible inhibitor of IP3-mediated Ca2+ release, IC50 = 358 nM. Experiments with guinea-pig ileum permeabilized with alpha toxin revealed that Xestospongin C inhibits the IP3 receptor but not the ryanodine receptor in SR membranes. It is a useful tool for probing the involvement of IP3 receptors in cellular signaling. Cell permeable
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