Manufactured by:TriBio Science
RUO

VX-702, p38a MAP kinase inhibitor

A potent and selective inhibitor of p38 MAP kinases, p38α MAPK and p38β (KD = 3.7 and 17 nM respectively). Inhibits IL-6, IL-1β and TNFα production in LPS-primed blood. Inhibits p38 in platelets stimulated by thrombin, collagen or thromboxane agonist U-46619 at 1 μM. Provides only modest...

SKU:
ABM148946-1
Manufacturer SKU
TBI2181-10MG | TBI2181-50MG
Product type
Biochemical Inhibitors
Targetp38a MAP kinase
Purity>98%

Manufacturer provenance

Manufactured by:
TriBio Science
Sold by:
ABMIUM
Fulfilled from:
Manufacturer facility or confirmed fulfilment location

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Product description

A potent and selective inhibitor of p38 MAP kinases, p38α MAPK and p38β (KD = 3.7 and 17 nM respectively). Inhibits IL-6, IL-1β and TNFα production in LPS-primed blood. Inhibits p38 in platelets stimulated by thrombin, collagen or thromboxane agonist U-46619 at 1 μM. Provides only modest clinical efficacy in rheumatoid arthritis. Delays platelet lesions and leads to better maintenance of stored platelets

Key facts & specifications
Also known as
6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide
Molecular weight
404.32
Form / buffer
powder
Activity
A potent and selective inhibitor of p38 MAP kinases, p38α MAPK and p38β (KD = 3.7 and 17 nM respectively). Inhibits IL-6, IL-1β and TNFα production in LPS-primed blood. Inhibits p38 in platelets stimulated by thrombin, collagen or thromboxane agonist U-46619 at 1 μM. Provides only modest clinical efficacy in rheumatoid arthritis. Delays platelet lesions and leads to better maintenance of stored platelets.
Molecular formula
C 19 H 12 F 4 N 4 O 2
Solubility
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 2 mg/ml)
Technical note
Stability: ≥ 2 years.
Identifiers & database references
Manufacturer SKU
TBI2181-10MG | TBI2181-50MG
CAS number
745833-23-2
Storage, stability & shipping
Storage conditions
-20°C
Shipped at
4°C
Long-term storage
-20°C
Compliance & documents
Datasheet
Open datasheet
Frequently asked questions
Who manufactured this product?

This product is manufactured by TriBio Science and sold through ABMIUM without relabelling.

Can ABMIUM ship this product internationally?

ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.

Can I check suitability before ordering?

Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.

Is this product for clinical use?

Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.

TriBio Science
$78.00