A potent and selective inhibitor of p38 MAP kinases, p38α MAPK and p38β (KD = 3.7 and 17 nM respectively). Inhibits IL-6, IL-1β and TNFα production in LPS-primed blood. Inhibits p38 in platelets stimulated by thrombin, collagen or thromboxane agonist U-46619 at 1 μM. Provides only modest...
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A potent and selective inhibitor of p38 MAP kinases, p38α MAPK and p38β (KD = 3.7 and 17 nM respectively). Inhibits IL-6, IL-1β and TNFα production in LPS-primed blood. Inhibits p38 in platelets stimulated by thrombin, collagen or thromboxane agonist U-46619 at 1 μM. Provides only modest clinical efficacy in rheumatoid arthritis. Delays platelet lesions and leads to better maintenance of stored platelets
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