A novel activator of CBP/p300 acetyl transferases. When TTK21 is conjugated to glucose-based carbon nanospheres (CSP) it is nontoxic and is BBB permeable. CSP-TTK21, upon intraperitoneal administration to mice, acetylated histones in the hippocampus and frontal cortex and increased BDNF levels....
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A novel activator of CBP/p300 acetyl transferases. When TTK21 is conjugated to glucose-based carbon nanospheres (CSP) it is nontoxic and is BBB permeable. CSP-TTK21, upon intraperitoneal administration to mice, acetylated histones in the hippocampus and frontal cortex and increased BDNF levels. It reinstated plasticity and memory in a tauopathy mouse model, ameliorated Aβ-impaired long term potentiation and promoted axon growth, sprouting and synaptic plasticity in chronic experimental spinal cord injury
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