THI was identified as a biologically active impurity in caramel food coloring. It is a potent inhibitor of sphingosine-1-phosphate (S1P) lyase. It disrupts lymphocyte egress from lymphoid tissue by interfering with S1P gradients. The novel immunomodulatory activity of THI and its biochemical...
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THI was identified as a biologically active impurity in caramel food coloring. It is a potent inhibitor of sphingosine-1-phosphate (S1P) lyase. It disrupts lymphocyte egress from lymphoid tissue by interfering with S1P gradients. The novel immunomodulatory activity of THI and its biochemical mechanism may represent a new target for the development of new generation of immunosuppressants
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