Selectively induces apoptosis in cells with truncations in the adenomatous polyposis coli (APC) gene (but not normal cells or wild type cancer cells), an important multifunctional tumor suppressor gene. IC50 = 70nM for DLD1 cell line. It inhibited cancer cell growth in human tumor xenografts...
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Selectively induces apoptosis in cells with truncations in the adenomatous polyposis coli (APC) gene (but not normal cells or wild type cancer cells), an important multifunctional tumor suppressor gene. IC50 = 70nM for DLD1 cell line. It inhibited cancer cell growth in human tumor xenografts (DLD1 and HT29 tumors) and a genetically engineered mouse model (CPC;Apc) of colorectal cancer. TASIN-1 induces ER stress-dependent JNK activation with ROS production and AKT inhibition via cholesterol depletion
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