Potent high affinity liver X receptor (LXRα and β) agonist, EC50~50 nM. Upregulates expression of ABCA1, a reverse cholesterol transporter, resulting in inhibition of cholesterol absorption. Inverse agonist at CAR. T0901317 was also shown to be an FXR agonist at lower potency than LXR thus...
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Potent high affinity liver X receptor (LXRα and β) agonist, EC50~50 nM. Upregulates expression of ABCA1, a reverse cholesterol transporter, resulting in inhibition of cholesterol absorption. Inverse agonist at CAR. T0901317 was also shown to be an FXR agonist at lower potency than LXR thus appropriate controls must be employed when using this compound as a pharmacological tool. Decreases amyloid beta production in a mouse model of Alzheimer’s disease. Inhibits cellular senescence in endothelial cells
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