Manufactured by:TriBio Science
RUO

STF-118804, NAMPT inhibitor

Potent and selective next generation inhibitor of nicotinamide phosphoribosyl transferase (NAMPT), inhibiting NAD+ biosynthesis from nicotinamide. It reduces the viability of most B-ALL cells with high potency (low nM range), eliminates leukemia stem cells from mouse bone marrow and induces...

SKU:
ABM148787-1
Manufacturer SKU
TBI5640-25MG | TBI5640-5MG
Product type
Biochemical Inhibitors
TargetNAMPT
Purity>98%

Manufacturer provenance

Manufactured by:
TriBio Science
Sold by:
ABMIUM
Fulfilled from:
Manufacturer facility or confirmed fulfilment location

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Product description

Potent and selective next generation inhibitor of nicotinamide phosphoribosyl transferase (NAMPT), inhibiting NAD+ biosynthesis from nicotinamide. It reduces the viability of most B-ALL cells with high potency (low nM range), eliminates leukemia stem cells from mouse bone marrow and induces regression of ALL xenografts. It induces apoptosis and reduced neuroblastoma stem cell neurosphere formation in high-risk neuroblastoma cell lines. STF-118804 reduces the growth of pancreatic ductal adenocarcinoma cells

Key facts & specifications
Also known as
4-(5-Methyl-4-(tosylmethyl)oxazol-2-yl)-N-(pyridin-3-ylmethyl)benzamide
Molecular weight
461.50
Form / buffer
powder
Activity
Potent and selective next generation inhibitor of nicotinamide phosphoribosyl transferase (NAMPT), inhibiting NAD+ biosynthesis from nicotinamide. It reduces the viability of most B-ALL cells with high potency (low nM range), eliminates leukemia stem cells from mouse bone marrow and induces regression of ALL xenografts. It induces apoptosis and reduced neuroblastoma stem cell neurosphere formation in high-risk neuroblastoma cell lines. STF-118804 reduces the growth of pancreatic ductal adenocarcinoma cells.
Molecular formula
C 25 H 23 N 3 O 4 S
Solubility
Soluble in DMSO (47 mg/ml)
Technical note
Stability: ≥ 2 years.
Identifiers & database references
Manufacturer SKU
TBI5640-25MG | TBI5640-5MG
CAS number
894187-61-2
Storage, stability & shipping
Storage conditions
-20°C
Shipped at
4°C
Long-term storage
-20°C
Compliance & documents
Datasheet
Open datasheet
Safety data sheet
Open SDS
Frequently asked questions
Who manufactured this product?

This product is manufactured by TriBio Science and sold through ABMIUM without relabelling.

Can ABMIUM ship this product internationally?

ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.

Can I check suitability before ordering?

Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.

Is this product for clinical use?

Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.

Research target context

NAMPTnicotinamide phosphoribosyltransferase

View target guide

NAMPT identifies nicotinamide phosphoribosyltransferase in Homo sapiens (Human). This target record connects NCBI Gene 10135, UniProtKB P43490 and related ABMIUM catalogue products.

Organism
Multiple species; representative: Homo sapiens (Human)
NCBI Gene
10135
UniProtKB
P43490
TriBio Science
£458.00