Inhibits histone deacetylases (HDAC) 1 and 3 (IC50~0.6 µM) and HDAC8 (IC50~1 µM) and is less toxic compared to trichostatin A. Induces cell cycle arrest and epigenetic changes in colon cancer cells. Together with DRB-inhibition of RNA synthesis, scriptaid enhances gene reprogramming in somatic...
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Inhibits histone deacetylases (HDAC) 1 and 3 (IC50~0.6 µM) and HDAC8 (IC50~1 µM) and is less toxic compared to trichostatin A. Induces cell cycle arrest and epigenetic changes in colon cancer cells. Together with DRB-inhibition of RNA synthesis, scriptaid enhances gene reprogramming in somatic cell nuclear transfer (SCNT) embryos. Increases exercise endurance in mice
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