Blocker of the ATP-sensitive potassium channel Kir6 with hypoglycemic activity. Clinically useful antidiabetic agent. It displays 30-fold selectivity for pancreatic Kir6.2/SUR1 over cardiac Kir6.1/SUR2B and Kir6/SUR2A channels. Repaglinide displayed neuroprotective effects in Huntington disease,...
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Blocker of the ATP-sensitive potassium channel Kir6 with hypoglycemic activity. Clinically useful antidiabetic agent. It displays 30-fold selectivity for pancreatic Kir6.2/SUR1 over cardiac Kir6.1/SUR2B and Kir6/SUR2A channels. Repaglinide displayed neuroprotective effects in Huntington disease, Parkinson’s disease, and ALS via blockade of the DREAM-ATF6 interaction
Solutions in DMSO may be stored under an inert atmosphere at -20°C for up to 3 months
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