Manufactured by:TriBio Science
RUO

Probucol, Blocks oxidation of cholesterol

Unique antilipidemic drug which inhibits the oxidation of LDL cholesterol preventing the genesis of macrophage-derived foam cells and thus suppressing the formation of atherosclerotic vascular lesions. It inhibits ABCA1-mediated cholesterol efflux without influencing scavenger receptor (class B...

SKU:
ABM147589-1
Manufacturer SKU
TBI2679-10G | TBI2679-1G
Product type
Biochemical Inhibitors
TargetBlocks oxidation of cholesterol
Purity>98%

Manufacturer provenance

Manufactured by:
TriBio Science
Sold by:
ABMIUM
Fulfilled from:
Manufacturer facility or confirmed fulfilment location

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Product description

Unique antilipidemic drug which inhibits the oxidation of LDL cholesterol preventing the genesis of macrophage-derived foam cells and thus suppressing the formation of atherosclerotic vascular lesions. It inhibits ABCA1-mediated cholesterol efflux without influencing scavenger receptor (class B type 1)-mediated efflux. It enhances mitophagy and improves survival, locomotor function and dopaminergic neuron loss in zebrafish and fly models of mitochondrial damage. It attenuates NF-κB/NLRP3 signalling and augments Nrf-2-mediated antioxidant defense in nerve injury models. Improves learning and memory in aging mice. It protects neuronal cells against peroxide-induced damage and directly activates glutathione peroxidase-1

Key facts & specifications
Also known as
DH-581
Molecular weight
516.8
Form / buffer
Powder
Activity
Unique antilipidemic drug which inhibits the oxidation of LDL cholesterol preventing the genesis of macrophage-derived foam cells and thus suppressing the formation of atherosclerotic vascular lesions. It inhibits ABCA1-mediated cholesterol efflux without influencing scavenger receptor (class B type 1)-mediated efflux. It enhances mitophagy and improves survival, locomotor function and dopaminergic neuron loss in zebrafish and fly models of mitochondrial damage. It attenuates NF-κB/NLRP3 signalling and augments Nrf-2-mediated antioxidant defense in nerve injury models. Improves learning and memory in aging mice. It protects neuronal cells against peroxide-induced damage and directly activates glutathione peroxidase-1.
Molecular formula
C 31 H 48 O 2 S 2
Solubility
Soluble in DMSO (up to 100 mg/ml), in Ethanol (up to 50 mg/ml)
Technical note
Stability: ≥ 2 years.
Identifiers & database references
Manufacturer SKU
TBI2679-10G | TBI2679-1G
CAS number
23288-49-5
Storage, stability & shipping
Storage conditions
RT
Shipped at
4°C
Long-term storage
RT
Compliance & documents
Datasheet
Open datasheet
Safety data sheet
Open SDS
Frequently asked questions
Who manufactured this product?

This product is manufactured by TriBio Science and sold through ABMIUM without relabelling.

Can ABMIUM ship this product internationally?

ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.

Can I check suitability before ordering?

Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.

Is this product for clinical use?

Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.

TriBio Science
£182.00