Selective activator of large conductance Ca( 2+ )-dependent potassium channels (BK Ca or K Ca 1.1). It was able to increase blood-brain tumor barrier permeability in rat brain tumor models. NS 1619 inhibited proliferation and induced apoptosis in A2780 ovarian cancer cells. Displays...
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Selective activator of large conductance Ca( 2+ )-dependent potassium channels (BK Ca or K Ca 1.1). It was able to increase blood-brain tumor barrier permeability in rat brain tumor models. NS 1619 inhibited proliferation and induced apoptosis in A2780 ovarian cancer cells. Displays cardioprotective effects in an ischemia-reperfusion model and neuroprotective effects in a traumatic brain injury model
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