Selective inhibitor of RIP1 kinase. IC 50 s = 667 nM and 134 nM for TNFα in FAD-deficient Jurkat cells and L929 cells respectively. It binds to a site distinct from that of 7-Cl-O-Nec1 locking the enzyme in an inactive conformation. Necrostatin-34 acts synergistically with 7-Cl-O-Nec1 to inhibit...
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Selective inhibitor of RIP1 kinase. IC 50 s = 667 nM and 134 nM for TNFα in FAD-deficient Jurkat cells and L929 cells respectively. It binds to a site distinct from that of 7-Cl-O-Nec1 locking the enzyme in an inactive conformation. Necrostatin-34 acts synergistically with 7-Cl-O-Nec1 to inhibit necroptosis
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