MLS-544460 is an allosteric inhibitor of the Eya2 tyrosine phosphatase (IC 50 =4.1 µM) which is ineffective against other tyrosine phosphatases including Eya3 and PTP1B. Treatment of patient-derived glioma stem cells induced loss of bipolar spindle formation along with G2/M cell cycle arrest....
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MLS-544460 is an allosteric inhibitor of the Eya2 tyrosine phosphatase (IC 50 =4.1 µM) which is ineffective against other tyrosine phosphatases including Eya3 and PTP1B. Treatment of patient-derived glioma stem cells induced loss of bipolar spindle formation along with G2/M cell cycle arrest. GSC proliferation was inhibited at concentrations 4 to 10-fold lower than normal brain cells. Treatment of Axolotls following amputation impairs limb regeneration indicating a role for Eya2 in vertebrate regeneration
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