Inhibitor of Hedgehog signaling (IC50 = 0.5-0.7 µM). Binds directly to Smoothened (Smo). Inhibits the response of target tissues to Sonic hedgehog signaling. Induces COX-2 overexpression in human erythroleukemia cells
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Inhibitor of Hedgehog signaling (IC50 = 0.5-0.7 µM). Binds directly to Smoothened (Smo). Inhibits the response of target tissues to Sonic hedgehog signaling. Induces COX-2 overexpression in human erythroleukemia cells
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