Potent Wnt pathway inhibitor (IC50 = 25 nM in cells that exhibit constitutive Wnt pathway activation) that targets Porcupine (a membrane-bound O-acyltransferase), preventing critical Wnt ligand palmitoylation. Also acts as an ATP-competitive inhibitor of mutant (M82F) Casein Kinase 1δ (IC50 =...
Know who made it. See the evidence. Buy through one marketplace.
Potent Wnt pathway inhibitor (IC50 = 25 nM in cells that exhibit constitutive Wnt pathway activation) that targets Porcupine (a membrane-bound O-acyltransferase), preventing critical Wnt ligand palmitoylation. Also acts as an ATP-competitive inhibitor of mutant (M82F) Casein Kinase 1δ (IC50 = 142 nM). Inhibits growth and migration of cancer cell lines such as HT29, Panc1, and MDA-MB-2312,. Inhibits osteogenic differentiation. When used with CHIR-99021 (#MC-1279), induces cardiac differentiation by blocking expression of pluripotency markers and upregulating cardiac transcription factors
This product is manufactured by TriBio Science and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
