Indoximod is a modulator of indoleamine 2,3-dioxygenase (IDO) activity. IDO can be used by tumors to avoid elimination by the host immune response, thus inhibition of IDO is an interesting cancer therapeutic option. Indoximod is not a direct inhibitor of IDO, but instead targets the IDO gene...
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Indoximod is a modulator of indoleamine 2,3-dioxygenase (IDO) activity. IDO can be used by tumors to avoid elimination by the host immune response, thus inhibition of IDO is an interesting cancer therapeutic option. Indoximod is not a direct inhibitor of IDO, but instead targets the IDO gene leading to downstream effects. IDO-mediated catabolism of tryptophan inhibits the immunoregulatory kinases mTOR and PKC5. This is relieved by Indoximod acting as a potent tryptophan mimetic restoring mTOR and PKC signaling
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