A potent GSK-3β inhibitor (IC50=22 nM). Also inhibits CDK1 (IC50=180 nM) and CDK5 (IC50=100 nM). Displays antimitotic properties and induces endoreplication following prophase arrest in HBL-100 cells. Possesses antiangiogenic activity. Attenuates β-amyloid-associated neuropathology in a mouse...
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A potent GSK-3β inhibitor (IC50=22 nM). Also inhibits CDK1 (IC50=180 nM) and CDK5 (IC50=100 nM). Displays antimitotic properties and induces endoreplication following prophase arrest in HBL-100 cells. Possesses antiangiogenic activity. Attenuates β-amyloid-associated neuropathology in a mouse model of Alzheimer’s disease. Cell permeable
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