Inhibits fatty acid binding proteins. Inhibits lipolysis in 3T3-L1 adipocytes and reduces LPS-stimulated inflammation in cultured macrophages. Acts as an antagonist of the protein-protein interaction between AFABP/aP2 and hormone sensitive lipase but does not activate PPARγ in macrophages....
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Inhibits fatty acid binding proteins. Inhibits lipolysis in 3T3-L1 adipocytes and reduces LPS-stimulated inflammation in cultured macrophages. Acts as an antagonist of the protein-protein interaction between AFABP/aP2 and hormone sensitive lipase but does not activate PPARγ in macrophages. Inhibits FABP-dependent and fatty acid-stimulated leukotriene C4 biosynthesis. Reduces intracellular free fatty acid levels, lowering macrophage inflammation and ER stress3. Reduces LPS-stimulated IL-1β secretion in a mouse model. Inhibits VLDL-induced foam cell formation
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