Potent reversible and selective TRPV4 antagonist. Active at mouse, human and rat TRPV4, IC50 = 17, 48 and 133 nM respectively. Also inhibits the endogenous TRPV4-mediated response to 4α-PDH (IC50 = 22 nM). Selective for TRPV4 over TRPV1, TRPV2, TRPV3 and TRPM8 channels. Increases functional...
Know who made it. See the evidence. Buy through one marketplace.
Potent reversible and selective TRPV4 antagonist. Active at mouse, human and rat TRPV4, IC50 = 17, 48 and 133 nM respectively. Also inhibits the endogenous TRPV4-mediated response to 4α-PDH (IC50 = 22 nM). Selective for TRPV4 over TRPV1, TRPV2, TRPV3 and TRPM8 channels. Increases functional bladder capacity and reduces micturition frequency in mice and rats with cystitis. Inhibits brain edema in middle cerebral artery occlusion mice. Induces an increase in core body temperature accompanied by increased oxygen consumption in Wistar rats. Active in vivo
This product is manufactured by TriBio Science and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
