Selective antagonist of GPR40. GW1100 inhibits GRP40-mediated Ca2+ increases stimulated GW9508 or linoleic acid (pIC50 = 5.99 for either agonist). The effects of GPR40 activation on insulin secretion in cells are also blocked by the addition of GW1100. GW1100 does not influence calcium...
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Selective antagonist of GPR40. GW1100 inhibits GRP40-mediated Ca2+ increases stimulated GW9508 or linoleic acid (pIC50 = 5.99 for either agonist). The effects of GPR40 activation on insulin secretion in cells are also blocked by the addition of GW1100. GW1100 does not influence calcium mobilization mediated by GPR120
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