GDC-0941 is a potent and selective inhibitor of class I phosphatidylinositol-3-kinases (PI3K) with significant antitumor activity – IC50’s: PI3Kα = 3nM, PI3Kβ = 33 nM, PI3Kδ = 3 nM, PI3Kγ = 75 nM. GDC-0941 is the chemical probe of choice for the pan-inhibition of class I PI3K’s. Currently in...
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GDC-0941 is a potent and selective inhibitor of class I phosphatidylinositol-3-kinases (PI3K) with significant antitumor activity – IC50’s: PI3Kα = 3nM, PI3Kβ = 33 nM, PI3Kδ = 3 nM, PI3Kγ = 75 nM. GDC-0941 is the chemical probe of choice for the pan-inhibition of class I PI3K’s. Currently in clinical trials
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