TGFß receptor 1 inhibitor / Cancer immunotherapeutic Galunisertib is a TGF-β kinase (TGFBR1, ALK5) inhibitor (IC50 = 56 nM). Blocks TGF-β-mediated SMAD2 activation and hematopoietic suppression in primary hematopoietic stem cells. Clinically useful anticancer agent, and is a promising...
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TGFß receptor 1 inhibitor / Cancer immunotherapeutic
Galunisertib is a TGF-β kinase (TGFBR1, ALK5) inhibitor (IC50 = 56 nM). Blocks TGF-β-mediated SMAD2 activation and hematopoietic suppression in primary hematopoietic stem cells. Clinically useful anticancer agent, and is a promising co-treatment with immune checkpoint inhibitors
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