Ferroptosis inducer. Inhibits the cystine-glutamate antiporter, system Xc- leading to activation of an ER stress response. Inhibition of system Xc- leads to cysteine starvation, glutathione depletion and induction of ferroptosis. Also blocks mitochondrial voltage-dependent anion channels...
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Ferroptosis inducer. Inhibits the cystine-glutamate antiporter, system Xc- leading to activation of an ER stress response. Inhibition of system Xc- leads to cysteine starvation, glutathione depletion and induction of ferroptosis. Also blocks mitochondrial voltage-dependent anion channels (specifically VDAC2 and 3)
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