Epoxomicin is a potent, selective and cell permeable irreversible inhibitor of the 20S proteasome. It does not inhibit non-proteasomal proteases such as papain, chymotrypsin, trypsin, calpain and cathepsin B at concentrations up to 50 µM. Epoxomicin was isolated from Actinomycete strain Q996-17...
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Epoxomicin is a potent, selective and cell permeable irreversible inhibitor of the 20S proteasome. It does not inhibit non-proteasomal proteases such as papain, chymotrypsin, trypsin, calpain and cathepsin B at concentrations up to 50 µM. Epoxomicin was isolated from Actinomycete strain Q996-17 and displayed in vivo antitumor activity against B16 melanoma cells. Epoxomicin caused a progressive model of Parkinson’s disease in various systems. This model has been disputed
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