A nucleoside analog that interferes with DNA synthesis and transcription, particularly in tumor cells. Cellular enzymes convert it to its phosphorylated form, Ara-CTP, which disrupts DNA and RNA synthesis when polymerases attempt to incorporate it. For the same reasons, it is also employed as an...
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A nucleoside analog that interferes with DNA synthesis and transcription, particularly in tumor cells. Cellular enzymes convert it to its phosphorylated form, Ara-CTP, which disrupts DNA and RNA synthesis when polymerases attempt to incorporate it. For the same reasons, it is also employed as an antiviral. It inhibits proliferation of a variety of leukemic cell lines (IC50s 16-72 nM), but is used primarily against acute myeloid leukemia (AML)
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