First-in-class selective RNA polymerase I inhibitor, suppressing Pol I transcription in MV 4;11 myelomonocytic leukemia cells and SR immunoblastic lymphoma cells with EC 50 values of 95 and 135 nM respectively and demonstrating 200-fold selectivity over Pol II. Activates the DNA damage response....
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First-in-class selective RNA polymerase I inhibitor, suppressing Pol I transcription in MV 4;11 myelomonocytic leukemia cells and SR immunoblastic lymphoma cells with EC 50 values of 95 and 135 nM respectively and demonstrating 200-fold selectivity over Pol II. Activates the DNA damage response. It induces a rapid accumulation of cytosolic DNA which results in upregulation of STING. Acts as a potent immunosuppressant inhibiting T cell-mediated alloimmunity and representing a novel class of immunosuppressant
This product is manufactured by TriBio Science and sold through ABMIUM without relabelling.
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