A potent and selective inhibitor of c-MET and ALK, IC50s=8 and 20 nM respectively. Inhibition of cell proliferation was associated with G1-S phase cell cycle arrest and induction of apoptosis in ALK-positive ALCL cells (IC50=30 nM) but not in ALK-negative lymphoma cells. Exhibits cytoreductive...
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A potent and selective inhibitor of c-MET and ALK, IC50s=8 and 20 nM respectively. Inhibition of cell proliferation was associated with G1-S phase cell cycle arrest and induction of apoptosis in ALK-positive ALCL cells (IC50=30 nM) but not in ALK-negative lymphoma cells. Exhibits cytoreductive antitumor efficacy via antiproliferative and antiangiogenic mechanisms. Clinically useful anticancer agent
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