Lipoic acid analog which potently disrupts mitochondrial metabolism with selectivity for tumor cells in vitro and shows strong antitumor activity in vivo. Inhibits alpha-ketoglutarate dehydrogenase (KGDH) by a redox mechanisms selectively in tumor cells. Inhibits pyruvate dehydrogenase (PDH) as...
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Lipoic acid analog which potently disrupts mitochondrial metabolism with selectivity for tumor cells in vitro and shows strong antitumor activity in vivo. Inhibits alpha-ketoglutarate dehydrogenase (KGDH) by a redox mechanisms selectively in tumor cells. Inhibits pyruvate dehydrogenase (PDH) as a mechanistically distinct, non-redox, effect. A novel anticancer agent with a mitochondria-targeted mode of action with non-genotoxic properties.. Has been used (along with PS48) to induce a Warburg-like metabolic state in fibroblasts. Combination treatment of CPI-613 and chloroquine inhibits the progression of clear cell sarcoma in a mouse model
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