A novel endogenous tryptophan metabolite which acts as an aryl hydrocarbon receptor (AHR) agonist. It drives IL-22 production by stimulating the differentiation of human and mouse T cells producing IL-22. Induces apoptosis in thymocytes. Activates type 4 metabotropic glutamate receptors....
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A novel endogenous tryptophan metabolite which acts as an aryl hydrocarbon receptor (AHR) agonist. It drives IL-22 production by stimulating the differentiation of human and mouse T cells producing IL-22. Induces apoptosis in thymocytes. Activates type 4 metabotropic glutamate receptors. Counteracts excitotoxic neuronal cell death induced by NMDA in mixed cultures of cortical cells. Displays neuroprotective activity
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