Arylhydrocarbon (AhR) receptor antagonist, IC50=30 nM. Blocks endogenous AhR agonist-induced differentiation of Th17 cells. Promotes expansion of human hematopoietic stem cells. Mitigates cytokine-mediated inflammatory signaling in human fibroblast-like synoviocytes. An important tool for...
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Arylhydrocarbon (AhR) receptor antagonist, IC50=30 nM. Blocks endogenous AhR agonist-induced differentiation of Th17 cells. Promotes expansion of human hematopoietic stem cells. Mitigates cytokine-mediated inflammatory signaling in human fibroblast-like synoviocytes. An important tool for probing the involvement of AhR in the toxicity of various environmental toxins such as TCDD and other dioxins
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