Allosteric activator of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA). It lowered fasting glucose levels, improved glucose tolerance, and ameliorated hepatitis steatosis in ob/ob mice. CDN1163 also rescued neurons from ER-stress-induced cell death in vitro and displayed significant...
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Allosteric activator of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA). It lowered fasting glucose levels, improved glucose tolerance, and ameliorated hepatitis steatosis in ob/ob mice. CDN1163 also rescued neurons from ER-stress-induced cell death in vitro and displayed significant efficacy in a rat 6-hydroxydopamine (6-OHDA) model of Parkinson’s disease. It reduced age-related muscle atrophy and weakness in a C57BL/6J mice. CDN1163 decreased inflammatory cytokines and chemokines and attenuated mitochondrial dysfunction in Influenza A infected H1395 cells
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