D,L-Buthionine sulfoximine is an irreversible inhibitor of γ-glutamylcysteine ligase (GCL). GCL is the first enzyme of the cellular glutathione biosynthetic pathway. Dysregulation of glutathione homeostasis is involved in many diseases including cancer, diabetes, neurodegenerative disorders and...
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D,L-Buthionine sulfoximine is an irreversible inhibitor of γ-glutamylcysteine ligase (GCL). GCL is the first enzyme of the cellular glutathione biosynthetic pathway. Dysregulation of glutathione homeostasis is involved in many diseases including cancer, diabetes, neurodegenerative disorders and HIV/AIDS. Most disease states involve decreased glutathione synthesis, however, in cancer, it is increased supporting cellular proliferation and protecting cancer cells. Pharmacological inhibition of GCL has been examined as a potential cancer treatment
Solutions are not stable and must be prepared fresh daily
This product is manufactured by TriBio Science and sold through ABMIUM without relabelling.
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